タナカ ジユンジ   TANAKA Junji
  田中 淳司
   所属   医学部 医学科(東京女子医科大学病院)
   職種   教授・基幹分野長
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Clinical impact of serum soluble SLAMF7 in multiple myeloma.
掲載誌名 正式名:Oncotarget
略  称:Oncotarget
ISSNコード:(1949-2553)1949-2553(Linking)
掲載区分国外
巻・号・頁 9(78),pp.34784-34793
著者・共著者 Ishibashi Mariko†, Soeda Saori, Sasaki Makoto, Handa Hiroshi, Imai Yoichi, Tanaka Norina, Tanosaki Sakae, Ito Shigeki, Odajima Takeshi, Sugimori Hiroki, Asayama Toshio, Sunakawa Mika, Kaito Yuta, Kinoshita Ryosuke, Kuribayashi Yasuko, Onodera Asaka, Moriya Keiichi, Tanaka Junji, Tsukune Yutaka, Komatsu Norio, Inokuchi Koiti, Tamura Hideto*
発行年月 2018/10
概要 The signaling lymphocytic activation molecule family (SLAMF7; also known as CS1 or CD319) is highly expressed on plasma cells from multiple myeloma (MM) as well as natural killer (NK) cells and is a well-known therapeutic target of elotuzumab. The objective of this study was to evaluate the clinical significance of serum soluble SLAMF7 (sSLAMF7) levels in patients with MM (n=103) and furthermore the impact of sSLMF7 on the antitumor activity of anti-SLAMF7 antibody. Thirty-one percent of MM patients, but not patients with monoclonal gammopathy of undetermined significance and healthy controls, had detectable levels of serum sSLAMF7, which were significantly increased in advanced MM patients. Further, MM in sSLAMF7-postive patients exhibited aggressive clinical characteristics with shorter progression-free survival times in comparison with sSLAMF7-negative patients. In responders to MM therapy, the levels of sSLAMF7 were undetectable or decreased compared with those before treatment. In addition, the anti-SLAMF7 antibody-mediated antibody-dependent cellular cytotoxicity of NK cells against MM cell lines was inhibited by recombinant SLAMF7 protein. Thus, our findings suggest that high concentrations of sSLAMF7, which could transiently suppress the therapeutic effects of elotuzumab, may be a useful indicator of disease progression in MM patients.
DOI 10.18632/oncotarget.26196
PMID 30410677