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タナカ ジユンジ
TANAKA Junji
田中 淳司 所属 その他 その他 職種 非常勤嘱託 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Outcomes of Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia Patients with Abnormalities of the Short Arm of Chromosome 17. |
| 掲載誌名 | 正式名：Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 略 称：Biol Blood Marrow Transplant ISSNコード：(1523-6536)1083-8791(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 23(8),pp.1398-1404 |
| 著者・共著者 | Mori Jinichi†, Yanada Masamitsu, Uchida Naoyuki, Fukuda Takahiro, Sakura Toru, Hidaka Michihiro, Watakabe-Inamoto Kyoko, Kanamori Heiwa, Ogawa Hiroyasu, Ichinohe Tatsuo, Tanaka Junji, Atsuta Yoshiko, Yano Shingo |
| 発行年月 | 2017/08 |
| 概要 | We retrospectively analyzed a Japanese nationwide database to elucidate the impact of abnormalities in the short arm of chromosome 17 (abnl[17p]) on the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with acute myeloid leukemia. Of 10,923 patients, 262 (2.4%) had abnl(17p), 235 of whom were classified into the poor cytogenetic risk group according to the National Comprehensive Cancer Network criteria. The median follow-up period was 1425 days. In abnl(17p) versus non-abnl(17p) patients of poor cytogenetic risk group, overall survival (OS), disease-free survival, cumulative incidence of disease relapse, and nonrelapse mortality rates at 5 years after allo-HSCT were 9.2% versus 27.4%, 7.8% versus 25.0%, 66.6% versus 49.4%, and 25.6% versus 25.6%, respectively. In contrast to the other types of abnl(17p), isochromosome 17q rarely encompassed the poor cytogenetic risk traits and did not adversely affect OS. Among the abnl(17p) patients, male sex, nonremission disease status at transplantation, and poor cytogenetic risk group were significantly associated with shorter OS. In conclusion, the presence of an abnl(17p) negatively affects allo-HSCT outcomes, which are influenced by the type of abnormality. Prompt initiation of allo-HSCT during complete remission may improve outcomes. |
| DOI | 10.1016/j.bbmt.2017.04.020 |
| PMID | 28455005 |