オカモト タカヒロ   Okamoto Takahiro
  岡本 高宏
   所属   医学部 医学科(東京女子医科大学病院)
   職種   教授・基幹分野長
論文種別 症例報告
言語種別 英語
査読の有無 査読あり
表題 Diagnosis of lateral pelvic lymph node metastasis of T1 lower rectal cancer using diffusion-weighted magnetic resonance imaging: A case report with lateral pelvic lymph node dissection of lower rectal cancer.
掲載誌名 正式名:Molecular and clinical oncology
略  称:Mol Clin Oncol
ISSNコード:(2049-9450)2049-9450(Linking)
掲載区分国外
巻・号・頁 4(5),pp.817-820
著者・共著者 OGAWA Shimpei†, ITABASHI Michio*, HIROSAWA Tomoichiro, HASHIMOTO Takuzo, BAMBA Yoshiko, OKAMOTO Takahiro
担当区分 最終著者
発行年月 2016/05
概要 The present study presented a 35-year-old female patient in whom fecal occult blood was detected in a medical check-up. Colonoscopy revealed a superficial elevated-type tumor with central depression in the lower rectum. The tumor was diagnosed as T1 deep invasive cancer. No swollen lymph nodes or distant metastasis were found on computed tomography or [(18)F]-fluorodeoxyglucose-positron emission tomography with computed tomography. However, a swollen right lateral pelvic lymph node (LPLN; short axis 4 mm) was revealed on magnetic resonance imaging (MRI). This lymph node exhibited high intensity on diffusion-weighted imaging (DWI), suggesting metastasis. Low anterior resection, regional lymph node dissection and right LPLN dissection (LPLD) were performed. Histological analysis revealed metastasis in the right LPLN, as suggested by the high DWI intensity. The indication for LPLD in the current Japanese guidelines is based on the tumor location and depth of invasion (≥T3), however, not on the status of LPLN metastasis in pre-operative evaluation. The present case was cT1, which is not included in this indication. DWI is sensitive for the diagnosis of lymph node metastasis of colorectal cancer, although inflammation-induced swelling of lymph nodes in advanced rectal cancer may cause a false-positive result, which is uncommon in T1 cases. Therefore, an LPLN with a high intensity DWI signal in T1 cases is likely to be metastasis-positive. Pre-operative DWI-MRI may be useful for identifying LPLN metastasis when planning the treatment strategy in these cases. The present study suggested reinvestigation of the indication for LPLD with inclusion of LPLN status on pre-operative imaging.
DOI 10.3892/mco.2016.797
PMID 27123286