ミタニ シヨウヘイ
MITANI Shohei
三谷 昌平 所属 医学部 医学科 職種 教授・基幹分野長 |
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論文種別 | 総説 |
言語種別 | 英語 |
査読の有無 | 査読あり |
招待の有無 | 招待あり |
表題 | Comprehensive functional genomics using Caenorhabditis elegans as a model organism. |
掲載誌名 | 正式名:Proceedings of the Japan Academy. Series B, Physical and biological sciences 略 称:Proc Jpn Acad Ser B Phys Biol Sci ISSNコード:(1349-2896)0386-2208(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 93(8),pp.561-577 |
著者・共著者 | Mitani Shohei |
担当区分 | 筆頭著者,責任著者 |
発行年月 | 2017/10 |
概要 | We have been working on functional genomics using C. elegans as a model organism. We first used cell-type specific markers and preexisting mutants to investigate how genotype-phenotype causal relationships are regulated. With the aid of transgenic methods, we analyzed various biological processes in C. elegans. We have developed efficient methods to isolate gene knockout strains. Thousands of strains isolated this way are used by many researchers and have revealed many biological mechanisms. We have also developed methods to examine the functions of genes in a comprehensive manner by integrating transgenes into chromosomes, designing conditional knockouts, and creating balancers for lethal mutations. A combination of these biological resources and techniques will be useful to understand the functions of genes in C. elegans, which has many genes that are orthologous to those of higher organisms including humans. |
DOI | 10.2183/pjab.93.036 |
PMID | 29021508 |