ミタニ シヨウヘイ   MITANI Shohei
  三谷 昌平
   所属   医学部 医学科
   職種   教授・講座主任
論文種別 総説
言語種別 英語
査読の有無 査読あり
招待の有無 招待あり
表題 Comprehensive functional genomics using Caenorhabditis elegans as a model organism.
掲載誌名 正式名:Proceedings of the Japan Academy. Series B, Physical and biological sciences
略  称:Proc Jpn Acad Ser B Phys Biol Sci
ISSNコード:(1349-2896)0386-2208(Linking)
掲載区分国外
巻・号・頁 93(8),561-577頁
著者・共著者 Mitani Shohei
発行年月 2017/10
概要 We have been working on functional genomics using C. elegans as a model organism. We first used cell-type specific markers and preexisting mutants to investigate how genotype-phenotype causal relationships are regulated. With the aid of transgenic methods, we analyzed various biological processes in C. elegans. We have developed efficient methods to isolate gene knockout strains. Thousands of strains isolated this way are used by many researchers and have revealed many biological mechanisms. We have also developed methods to examine the functions of genes in a comprehensive manner by integrating transgenes into chromosomes, designing conditional knockouts, and creating balancers for lethal mutations. A combination of these biological resources and techniques will be useful to understand the functions of genes in C. elegans, which has many genes that are orthologous to those of higher organisms including humans.
DOI 10.2183/pjab.93.036
PMID 29021508