ミタニ シヨウヘイ   MITANI Shohei
  三谷 昌平
   所属   医学部 医学科
   職種   教授・講座主任
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization.
掲載誌名 正式名:Science (New York, N.Y.)
略  称:Science
ISSNコード:(1095-9203)0036-8075(Linking)
掲載区分国外
巻・号・頁 353(6297),394-399頁
著者・共著者 Zhou Qinghua, Li Haimin, Li Hanzeng, Nakagawa Akihisa, Lin Jason L J, Lee Eui-Seung, Harry Brian L, Skeen-Gaar Riley Robert, Suehiro Yuji, William Donna, Mitani Shohei, Yuan Hanna S, Kang Byung-Ho, Xue Ding
発行年月 2016/07
概要 Mitochondria are inherited maternally in most animals, but the mechanisms of selective paternal mitochondrial elimination (PME) are unknown. While examining fertilization in Caenorhabditis elegans, we observed that paternal mitochondria rapidly lose their inner membrane integrity. CPS-6, a mitochondrial endonuclease G, serves as a paternal mitochondrial factor that is critical for PME. We found that CPS-6 relocates from the intermembrane space of paternal mitochondria to the matrix after fertilization to degrade mitochondrial DNA. It acts with maternal autophagy and proteasome machineries to promote PME. Loss of cps-6 delays breakdown of mitochondrial inner membranes, autophagosome enclosure of paternal mitochondria, and PME. Delayed removal of paternal mitochondria causes increased embryonic lethality, demonstrating that PME is important for normal animal development. Thus, CPS-6 functions as a paternal mitochondrial degradation factor during animal development.
DOI 10.1126/science.aaf4777
PMID 27338704