ミタニ シヨウヘイ   MITANI Shohei
  三谷 昌平
   所属   医学部 医学科
   職種   教授・講座主任
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database.
掲載誌名 正式名:Glycobiology
略  称:Glycobiology
ISSNコード:1460-2423(Electronic)0959-6658(Linking)
巻・号・頁 25(1),8-20頁
著者・共著者 Akiyoshi Sayaka, Nomura Kazuko H, Dejima Katsufumi, Murata Daisuke, Matsuda Ayako, Kanaki Nanako, Takaki Tetsuro, Mihara Hiroyuki, Nagaishi Takayuki, Furukawa Shuhei, Ando Keiko-Gengyo, Yoshina Sawako, Mitani Shohei, Togayachi Akira, Suzuki Yoshinori, Shikanai Toshihide, Narimatsu Hisashi, Nomura Kazuya
発行年月 2015/01
概要 UNLABELLED:In this study, we selected 181 nematode glycogenes that are orthologous toUNLABELLED:human glycogenes and examined their RNAi phenotypes. The results are deposited in the Caenorhabditis elegans Glycogene Database (CGGDB) at AIST, Tsukuba, Japan. The most prominent RNAi phenotypes observed are disruptions of cell cycle progression in germline mitosis/meiosis and in early embryonic cell mitosis. Along with the previously reported roles of chondroitin proteoglycans, glycosphingolipids and GPI-anchored proteins in cell cycle progression, we show for the first time that the inhibition of the functions of N-glycan synthesis genes (cytoplasmic alg genes) resulted in abnormal germline formation, ER stress and small body size phenotypes. The results provide additional information on the roles of glycoconjugates in the cell cycle progression mechanisms of germline and embryonic cells.
DOI 10.1093/glycob/cwu080
文献番号 25091817