イワドウ カズヒロ   IWADOH Kazuhiro
  岩藤 和広
   所属   医学部 医学科(東京女子医科大学病院)
   職種   非常勤講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
招待の有無 招待あり
表題 Long-Term Outcome in Kidney Transplantation From Expanded-Criteria Donors After Circulatory Death
掲載誌名 正式名:Transplantation proceedings
略  称:Transplant Proc
ISSNコード:00411345
掲載区分国外
出版社 Elsevier
巻・号・頁 45-48(49),pp.45-48
著者・共著者 Tomita Yusuke†*, Iwadoh Kazuhiro, Nakajima Ichiro, Fuchinoue Shohei
発行年月 2017/01
概要 The number of recipients waiting for a transplant is increasing. In Japan, there is more frequent use of organs from expanded-criteria donors (ECDs) after circulatory death. We retrospectively analyzed long-term outcomes of kidney transplantation (KT) from expanded-criteria donation after circulatory death (DCD). From 1995 to 2013, 97 cases of KT from DCD donors were performed in our department. Death-censored graft survival rates of ECD kidneys (n = 50) versus standard-criteria deceased-donor (SCD) kidneys (n = 47) for 1, 5, and 10 years after transplantation were 84.0% vs 97.9%, 74.8% vs 95.6%, and 70.2% vs 81.8%, respectively. No significant difference was found between the 2 groups (P = .102). Kidneys from donors with a history of hypertension (HTN) and cerebrovascular events (CVE) and contribution from older donors had significantly lower 10-year graft survival rates (P values of .010, .036, and .050, respectively). Cox proportional hazard regression analyses showed donor age to be significantly associated with long-term graft survival independently from other factors. These results suggest that ECD kidneys remain an acceptable alternative to dialysis under certain conditions. Increased donor age was a significant risk factor determining long-term graft function. Moreover, comorbidities of HTN and CVE could become significant risk factors, especially in older donors.
DOI 10.1016/j.transproceed.2016.10.009