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トクシゲ カツトシ
TOKUSHIGE Katsutoshi
徳重 克年 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Eradication of hepatitis C virus with direct-acting antivirals improves glycemic control in diabetes: A multicenter study. |
| 掲載誌名 | 正式名：JGH open : an open access journal of gastroenterology and hepatology 略 称：JGH Open ISSNコード：23979070/23979070 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 5(2),pp.228-234 |
| 著者・共著者 | TAKAHASHI Hirokazu, NAKAHARA Takashi, KOGISO Tomomi, IMAJO Kento, KESSOKU Takaomi, KAWAGUCHI Takumi, IDE Tatsuya, KAWANAKA Miwa, FYOGO Hideyuki, FUJII Hideki, ONO Masafumi, KAMEDA Yoshihiro, SUMIDA Yoshio, ANZAI Keizo, SHIMIZU Masahito, TOEIMURA Takuji, NAKAJIMA Atsushi, TOKUSHIGE Katsutoshi, CHAYAMA Kazuaki, EGUCHI Yuichiro, Japan Study Group of NAFLD (JSG‐NAFLD) |
| 発行年月 | 2021/02 |
| 概要 | Background and Aim:Hepatitis C virus (HCV) infection causes insulin resistance and diabetes as extrahepatic manifestations. We aimed to analyze the effect of HCV eradication by direct-acting antiviral (DAA) agents on glucose tolerance.Methods:The hemoglobin A1c (HbA1c) of 272 patients with HCV infection who achieved a sustained virologic response (SVR) was analyzed at baseline before DAA treatment, at the end of DAA therapy (ETR), and 12 weeks after therapy (Post12W).Results:There were no significant differences in HbA1c between baseline, ETR, and Post12W in the overall patients. When the data were stratified according to the presence or absence of diabetes, median HbA1c significantly decreased from baseline (7.2%) to ETR (6.8%) and Post12W (6.8%) in the 55 patients with diabetes, whereas there were no significant changes in the patients without diabetes. Basal HbA1c, fasting plasma glucose, and age were independently associated with the changes in HbA1c according to multivariate analysis, and the predictive formula for changes in HbA1c was found to be ΔHbA1c (%) = 1.449-0.4* HbA1c (%) + 0.012 × Age (year). There were no changes in body mass in diabetic or nondiabetic patients. In diabetic patients taking medication, 63.4% of patients needed less medication.Conclusions:Eradication of HCV improves glycemic control, indicated by a 0.4% decrease in HbA1c in diabetes. |
| DOI | 10.1002/jgh3.12474 |
| PMID | 33553660 |