トクシゲ　カツトシ   TOKUSHIGE Katsutoshi   徳重　克年    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Atypical Sarcoidosis Diagnosed by Massive Splenomegaly.
掲載誌名	正式名：Internal medicine 略　 称：Intern Med ISSNコード：13497235/09182918
掲載区分	国内
巻・号・頁	59(5),pp.641-648
著者・共著者	SAITO Satomi†, KODAMA Kazuhisa, KOGISO Tomomi*, YAMANASHI Yuki, TANIAI Makiko, ARIIZUMI Shunichi, YAMAMOTO Masakazu, TOKUSHIGE Katsutoshi
担当区分	最終著者
発行年月	2020/03
概要	We examined a 22-year-old woman who was admitted to our hospital with abdominal distention. At 19 years of age, the patient presented with hepatosplenomegaly. She was examined several times in another hospital; however, the cause was unidentified. Our evaluation showed severe pancytopenia and a spleen 13×24 cm in size. The serum levels of angiotensin-converting enzyme and lysozyme were elevated. She was diagnosed with liver sarcoidosis based on non-caseating epithelioid granuloma in liver biopsy tissue. To improve the symptoms, splenectomy was performed, and her pancytopenia and symptoms improved. Sarcoidosis should be considered in cases of massive splenomegaly.
DOI	10.2169/internalmedicine.3646-19
PMID	31666466