ISHIDA Hideki
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Prognostic impact of sarcopenia in patients with metastatic hormone-sensitive prostate cancer.
Journal Formal name：Japanese journal of clinical oncology
Abbreviation：Jpn J Clin Oncol
ISSN code：14653621/03682811
Domestic / ForeginForegin
Volume, Issue, Page 50(8),pp.933-939
Author and coauthor IKEDA Takashi†, ISHIHARA Hiroki, IIZUKA Junpei*, HASHIMOTO Yasunobu, YOSHIDA Kazuhiko, KAKUTA Yoichi, TAKAGI Toshio, OKUMI Masayoshi, ISHIDA Hideki, KONDO Tsunenori, TANABE KAZUNARI*
Publication date 2020/08
Summary BACKGROUND:Cancer cachexia is associated with a poor prognosis. This study aimed to investigate the association between sarcopenia and survival in patients with metastatic hormone-sensitive prostate cancer.RESULTS:In total, 163 patients (82.7%) had sarcopenia. Cancer-specific survival and overall survival were significantly shorter in sarcopenic patients than in non-sarcopenic patients (median cancer-specific survival: 77.0 months vs. not reached, P = 0.0099; overall survival: 72.0 months vs. not reached, P = 0.0465), whereas castration-resistance prostate cancer-free survival did not significantly differ between the groups (P = 0.6063). Multivariate analyses showed that sarcopenia was an independent factor for cancer-specific survival (hazard ratio: 2.18, P = 0.0451), together with the Gleason score (hazard ratio: 1.87, P = 0.0272) and LATITUDE risk classification (hazard ratio: 2.73, P = 0.0008). Moreover, the prognostic association of sarcopenia was remarkable in patients aged <73.0 years (cancer-specific survival: 82.0 months vs. not reached, P = 0.0027; overall survival: 72.0 months vs. not reached, P = 0.0078 in sarcopenic vs. non-sarcopenic patients), whereas the association was not significant in patients aged ≥73.0 years (cancer-specific survival: 76.0 and 75.0 months, respectively, P = 0.7879; overall survival: 67.0 and 52.0 months, respec
DOI 10.1093/jjco/hyaa045
PMID 32303747