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Ichiba Shingo
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Assessment of 28-Day In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019: An International Cohort Study. |
| Journal | Formal name：Critical care explorations Abbreviation：Crit Care Explor ISSN code：26398028/26398028 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 3(11),pp.e0567 |
| Author and coauthor | Li Bassi Gianluigi, Suen Jacky Y, White Nicole, Dalton Heidi J, Fanning Jonathon, Corley Amanda, Shrapnel Sally, Hinton Samuel, Forsyth Simon, Parsons Rex, Laffey John G, Fan Eddy, Bartlett Robert, Brodie Daniel, Burrell Aidan, Chiumello Davide, Elhazmi Alyaa, Grasselli Giacomo, Hodgson Carol, Ichiba Shingo, Luna Carlos, Marwali Eva, Merson Laura, Murthy Srinivas, Nichol Alistair, Panigada Mauro, Pelosi Paolo, Torres Antoni, Ng Pauline Yeung, Ogino Mark, Fraser John F |
| Publication date | 2021/11 |
| Summary | Factors associated with mortality in coronavirus disease 2019 patients on invasive mechanical ventilation are still not fully elucidated.OBJECTIVES:To identify patient-level parameters, readily available at the bedside, associated with the risk of in-hospital mortality within 28 days from commencement of invasive mechanical ventilation or coronavirus disease 2019.DESIGN SETTING AND PARTICIPANTS:Prospective observational cohort study by the global Coronavirus Disease 2019 Critical Care Consortium. Patients with laboratory-confirmed coronavirus disease 2019 requiring invasive mechanical ventilation from February 2, 2020, to May 15, 2021.MAIN OUTCOMES AND MEASURES:Patient characteristics and clinical data were assessed upon ICU admission, the commencement of invasive mechanical ventilation and for 28 days thereafter. We primarily aimed to identify time-independent and time-dependent risk factors for 28-day invasive mechanical ventilation mortality.RESULTS:One-thousand five-hundred eighty-seven patients were included in the survival analysis; 588 patients died in hospital within 28 days of commencing invasive mechanical ventilation (37%). Cox-regression analysis identified associations between the hazard of 28-day invasive mechanical ventilation mortality with age (hazard ratio, 1.26 per 10-yr increase in age; p < 0.001), positive end-expiratory pressure upon commencement of invasive mechanical ventilation (hazard ratio, 0.81 per 5 cm H2O increase; p = 0.02). Time-dependent parameters associated with 28-day invasive mechanical ventilation mortality were serum creatinine (p < 0.001), lactate (p < 0.001), Paco2 (p < 0.001), pH (p = 0.041), Pao2/Fio2 (p < 0.001), and mean arteria |
| DOI | 10.1097/CCE.0000000000000567 |
| PMID | 34765979 |