イチバ　シンゴ   Ichiba Shingo   市場　晋吾    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Blood oxygenation using microbubble suspensions.
掲載誌名	正式名：European biophysics journal : EBJ 略　 称：Eur Biophys J ISSNコード：14321017/01757571
掲載区分	国外
巻・号・頁	41(6),pp.571-578
著者・共著者	Matsuki Noriaki, Ichiba Shingo, Ishikawa Takuji, Nagano Osamu, Takeda Motohiro, Ujike Yoshihito, Yamaguchi Takami
発行年月	2012/06
概要	Microbubbles have been used in a variety of fields and have unique properties, for example shrinking collapse, long lifetime, efficient gas solubility, a negatively charged surface, and the ability to produce free radicals. In medicine, microbubbles have been used mainly as diagnostic aids to scan various organs of the body, and they have recently been investigated for use in drug and gene delivery. However, there have been no reports of blood oxygenation by use of oxygen microbubble fluids without shell reagents. In this study, we demonstrated that nano or microbubbles can achieve oxygen supersaturation of fluids, and may be sufficiently small and safe for infusion into blood vessels. Although Po(2) increases in fluids resulting from use of microbubbles were inhibited by polar solvents, normal saline solution (NSS) was little affected. Thus, NSS is suitable for production of oxygen-rich fluid. In addition, oxygen microbubble NSS effectively improved hypoxic conditions in blood. Thus, use of oxygen microbubble (nanobubble) fluids is a potentially effective novel method for oxygenation of hypoxic tissues, for infection control, and for anticancer treatment.
DOI	10.1007/s00249-012-0811-y
PMID	22476882