イチバ シンゴ
Ichiba Shingo
市場 晋吾 所属 医学部 医学科(東京女子医科大学病院) 職種 教授 |
|
論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Hemodynamic effects of pumpless extracorporeal membrane oxygenation (ECMO) support for chronically pressure-overloaded right heart failure in a canine experimental model. |
掲載誌名 | 正式名:Surgery today 略 称:Surg Today ISSNコード:09411291/09411291 |
掲載区分 | 国内 |
巻・号・頁 | 35(10),pp.861-868 |
著者・共著者 | Tamesue Kiyokazu, Nawa Sugato, Ichiba Shingo, Aoe Motoi, Date Hiroshi, Shimizu Nobuyoshi |
発行年月 | 2005 |
概要 | PURPOSE:This study was done to evaluate the hemodynamic effects of a pumpless implantable extracorporeal membrane oxygenation (ECMO) circuit between the right ventricle (RV) and left atrium (LA) in a chronic canine model with an RV pressure overload.METHOD:We created a model of right-sided heart failure by pulmonary artery banding in ten dogs for a duration of more than 3 months. After demonstrating that the RV pressure increased, a bypass circuit was created between the RV and LA with an in-line oxygenator. Both the hemodynamics and gas exchange were measured.RESULTS:The effects of a pulmonary bypass in nine dogs were studied. Approximately half of the RV output was passively shunted through the bypass circuit, and a marked reduction in the RV pressure and recovery from right heart failure were observed. After a complete ligation of the main pulmonary artery, five of the nine dogs survived more than 6 h. The RV pressure did not change significantly, but the cardiac output and blood pressure gradually decreased. The blood gas state was sufficiently maintained throughout the experiment.CONCLUSION:The present study indicates the hemodynamic benefit of a partial pumpless ECMO system in dogs with chronically pressure-overloaded right heart failure; however, the experimental preparation of the total pumpless ECMO circuit proved to be unstable. |
DOI | 10.1007/s00595-005-3046-z |
PMID | 16175468 |