イチバ　シンゴ   Ichiba Shingo   市場　晋吾    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effect of blood flow rate on thrombogenesis in a rabbit extracorporeal circulation model.
掲載誌名	正式名：ASAIO journal (American Society for Artificial Internal Organs : 1992) 略　 称：ASAIO J ISSNコード：10582916/10582916
掲載区分	国外
巻・号・頁	45(5),pp.478-481
著者・共著者	Kawai T, Annich G M, Meinhardt J P, Ichiba S, Brant D O, Bartlett R H
発行年月	1999/09
概要	Blood flow is believed to affect the thrombogenicity of extracorporeal circulation (ECC). The purpose of this study was to look at the relationship between blood flow and thrombogenicity in a rabbit model of ECC. Rabbits were anesthetized and systematically heparinized. Bilateral jugular cannulation was performed, and the animals were placed on venovenous ECC. The circuits were composed of 1 m of 1/4 inch size surgical grade polyvinylchloride (PVC) tubing. ECC was maintained for 4 hours. Three experimental groups were studied: a high flow group (n=7; flow rate: 30 ml/min/Kg), low flow group (n=7; flow rate: 10 ml/mg/Kg), and no ECC group (n=7). Platelet count, fibrinogen concentration, PaO2/FiO2, and postmortem findings were evaluated. Platelet consumption was higher with high flow, and fibrinogen consumption was higher with low flow.
DOI	10.1097/00002480-199909000-00021
PMID	10503629