YAMAGUCHI SHIGEKI    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Non peer reviewed
Title	Characteristics of anal canal cancer in Japan.
Journal	Formal name：Cancer medicine Abbreviation：Cancer Med ISSN code：20457634/20457634
Domestic / Foregin	Foregin
Volume, Issue, Page	11(14),pp.2735-2743
Author and coauthor	Yamada Kazutaka, Saiki Yasumitsu, Komori Koji, Shiomi Akio, Ueno Masashi, Ito Masaaki, Hida Koya, Yamamoto Seiichiro, Shiozawa Manabu, Ishihara Soichiro, Kanemitsu Yukihide, Ueno Hideki, Kinjo Tatsuya, Maeda Kotaro, Kawamura Junichiro, Fujita Fumihiko, Takahashi Keiichi, Mizushima Tsunekazu, Shimada Yasuhiro, Sasaki Shin, Sunami Eiji, Ishida Fumio, Hirata Keiji, Ohnuma Shinobu, Funahashi Kimihiko, Watanabe Jun, Kinugasa Yusuke, Yamaguchi Shigeki, Hashiguchi Yojiro, Ikeda Masataka, Sudo Takeshi, Komatsu Yoshito, Koda Keiji, Sakamoto Kazuhiro, Okajima Masazumi, Ishida Hideyuki, Hisamatsu Yuichi, Masuda Taiki, Mori Shinichiro, Minami Kazuhito, Hasegawa Seiji, Endo Shungo, Iwashita Akinori, Hamada Madoka, Ajioka Yoichi, Usuku Koichiro, Ikeda Tokunori, Sugihara Kenichi
Publication date	2022/07
Summary	Anal canal cancer (ACC) has been reported to be an uncommon cancer in Japan, as in the USA, Europe, and Australia. This retrospective multi-institutional study was conducted to clarify the characteristics of ACC in Japan. First, the histological ACC type cases treated between 1991 and 2015 were collected. A detailed analysis of the characteristics of anal canal squamous cell carcinoma (SCC) cases was then conducted. The results of the histological types revealed that of the 1781 ACC cases, 435 cases (24.4%) including seven cases of adenosquamous cell carcinomas were SCC and 1260 cases (70.7%) were adenocarcinoma. However, the most common histological type reported in the USA, Europe, and Australia is SCC. Most ACC cases are adenocarcinomas and there is a low incidence of SCC in Japan which is different from the above-mentioned countries. Moreover, we reclassified T4 into the following two groups based on tumor size: T4a (tumor diameter of 5 cm or less) and T4b (tumor diameter of more than 5 cm). The results of the TNM classification of SCC revealed that the hazard ratio (HR) to T1 of T2, T3, T4a, and T4b was 2.45, 2.28, 2.89, and 4.97, respectively. As T4b cases had a worse prognosis than T4a cases, we propose that T4 for anal canal SCC in Japan be subclassified into T4a and T4b.
DOI	10.1002/cam4.4631
PMID	35274487