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ヤマグチ シゲキ
YAMAGUCHI SHIGEKI
山口 茂樹 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | C-reactive protein adjusted for body mass index as a predictor of postoperative complications following laparoscopic gastrectomy for gastric cancer. |
| 掲載誌名 | 正式名：Langenbeck's archives of surgery 略 称：Langenbecks Arch Surg ISSNコード：14352451/14352443 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 406(6),pp.1875-1884 |
| 著者・共著者 | Matsui Kazuaki, Sakuramoto Shinichi, Sugita Hirofumi, Nishibeppu Keiji, Ebara Gen, Fujita Shohei, Fujihata Shiro, Oya Shuichiro, Miyawaki Yutaka, Sato Hiroshi, Yamaguchi Shigeki, Yamashita Keishi |
| 発行年月 | 2021/09 |
| 概要 | PURPOSE:This study aimed to clarify the relationship between obesity and postoperative C-reactive protein (CRP) and assess the usefulness of obesity status-adjusted CRP levels for predicting early complications following laparoscopic gastrectomy for gastric cancer.METHODS:This study retrospectively analyzed 527 patients who underwent laparoscopic gastrectomy for gastric cancer between January 2013 and March 2019. Patients were classified into three groups according to body mass index (BMI): BMI < 20; BMI ≥ 20 to < 25; and BMI ≥ 25. The correlation between BMI and perioperative CRP was investigated in 447 patients, excluding 80 with postoperative complications. The optimal CRP cutoff value of Clavien-Dindo (CD) grade ≥ 3 for predicting severe complications for each group was determined.RESULTS:BMI was significantly correlated with CRP on postoperative day (POD) 3 (p < 0.001) in 447 patients without complications. According to the receiver operating characteristic curve analysis, CRP cutoff values on POD 3 for predicting severe complications were 92.4, 111.1, and 171.9 in the BMI < 20, BMI ≥ 20 to < 25, and BMI ≥ 25 groups, respectively. In multivariate analysis for CD grade ≥ 3 complications, cardiac history and POD 3 CRP levels higher than the adjusted cutoff were identified as independent factors significantly associated with severe complications (p = 0.021 and 0.015, respectively).CONCLUSION:CRP cutoff values on POD 3 adjusted for BMI were useful for predicting severe complications in gastrectomy for gastric cancer. |
| DOI | 10.1007/s00423-021-02200-1 |
| PMID | 34021415 |