ヤマグチ　シゲキ   YAMAGUCHI SHIGEKI   山口　茂樹    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Impact of Lymphovascular Invasion in Patients With Stage II Colorectal Cancer: A Propensity Score-matched Study.
掲載誌名	正式名：In vivo (Athens, Greece) 略　 称：In Vivo ISSNコード：17917549/0258851X
掲載区分	国外
巻・号・頁	35(1),pp.525-531
著者・共著者	Kataoka Masahiro, Hirano Yasumitsu, Ishii Toshimasa, Kondo Hiroka, Asari Masahiro, Ishikawa Shintaro, Kataoka Atsuko, Fujii Takatsugu, Shimamura Satoshi, Yamaguchi Shigeki
発行年月	2021
概要	BACKGROUND/AIM:Whether lymphovascular invasion (LVI) is a high-degree risk factor in stage II colorectal cancer has not been fully clarified, as different results have been reported in the literature. If LVI is a risk factor, postoperative chemotherapy may be recommended. The purpose of this study was to evaluate the impact of lymphovascular invasion on disease recurrence and patient prognosis in conjunction with stage II colorectal cancer (CRC).PATIENTS AND METHODS:A total of 636 patients with stage II CRC, each undergoing radical resection between April 2007 and December 2015, were selected for the study. Subjects with or without venous or lymphatic invasion were assigned to positive and negative groups, respectively. We then compared overall survival (OS) and disease-free survival (DFS) using propensity score matching.RESULTS:After matching (n=226, each group), OS and DFS were found to be significantly lower (OS: p=0.047; DFS: p=0.004) in patients positive (vs. negative) for venous invasion. However, the same was not true of lymphatic invasion. After matching, positive and negative groups (n=92, each) did not significantly differ in terms of OS (p=0.951) or DFS (p=0.258).CONCLUSION:In patients with stage II CRC, venous invasion proved to be a significant high-degree risk factor that may warrant adjuvant chemotherapy.
DOI	10.21873/invivo.12287
PMID	33402505