NAGATA Satoru    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Case report
Language	English
Peer review	Peer reviewed
Title	Immunosuppressive medication is not associated with surgical site infection after surgery for intractable ulcerative colitis in children.
Journal	Formal name：Intractable & rare diseases research Abbreviation：Intractable Rare Dis Res ISSN code：21863644/21863644
Domestic / Foregin	Foregin
Volume, Issue, Page	6(2),pp.106-113
Author and coauthor	Uchida Keiichi, Ohtsuka Yoshikazu, Yoden Atsushi, Tajiri Hitoshi, Kimura Hideaki, Isihige Takashi, Yamada Hiroyuki, Arai Katsuhiro, Tomomasa Takeshi, Ushijima Kosuke, Aomatsu Tomoki, Nagata Satoru, Otake Kohei, Matsushita Kohei, Inoue Mikihiro, Kudo Takahiro, Hosoi Kenji, Takeuchi Kazuo, Shimizu Toshiaki
Publication date	2017/05
Summary	Pediatric ulcerative colitis (UC) sometimes progresses to an intractable condition for medical therapy. The surgical management of UC is challenging because of difficult procedures and frequent infectious complications. The aim of this study was to survey surgical procedures and infectious complications in pediatric patients with UC in Japan and to assess the relationship between preoperatively administered immunosuppressive drugs and postoperative surgical site infection (SSI). A survey of pediatric patients treated from 2000 to 2012 was sent to 683 facilities nationwide. Secondary questionnaires were sent to physicians who followed up patients with UC who had undergone surgery with the aim of assessing the relationships between postoperative SSI and selected preoperative patient characteristics, disease severity, medications, and operative procedures. Data for 136 patients (77 boys and 59 girls) were assessed. Median age at surgery was 14.1 years (range: 2.4-18.9 years). Surgery was performed in one stage in 35 cases, two stages in 57 cases, and three stages in 44 cases. SSI occurred in 36/136 patients (26%). According to multiple logistic regression analysis, there were statistically significant associations between SSI and staged surgery (three/one, OR: 6.7, 95% CI: 2.1-25.5, p = 0.0007; three/two, OR: 3.4, 95% CI: 1.4-8.6, p = 0.0069) and female sex (OR: 2.3, 95% CI: 1.0-5.4, p = 0.0434). Preoperative medications and incidence of SSI were not significantly associated. Preoperative immunosuppressive medication does not affect the incidence of SSI. Three-stage surgery and female sex are independent predictors of development of postoperative SSIs in pediatric patients with UC.
DOI	10.5582/irdr.2017.01012
PMID	28580210