Nagashima, Yoji
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Atypical protein kinase C λ/ι expression is associated with malignancy of oral squamous cell carcinoma. |
Journal | Formal name:Anticancer research Abbreviation:Anticancer Res ISSN code:02507005/17917530 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 38(11),pp.6291-6297 |
Author and coauthor | Baba J†, Kioi M*, Akimoto K, Nagashma Y, Taguri M, Inayama Y, Aoki I, Ohno S, Mitsudo K, Tohnai I |
Publication date | 2018/11 |
Summary | BACKGROUND/AIM: Atypical protein kinase C λ/ι (aPKCλ/ι) is a cell
polarity-regulator localized in the tight junction and apical membrane in epithelial cells. Previous studies suggested that aPKCλ/ι overexpression and abnormal localization were involved in tumor progression in several cancers. We investigated the relationship between aPKCλ/ι and oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: The correlation between the aPKCλ/ι expression and the clinicopathological parameters in 76 OSCC cases was examined using immunohistochemical analyses. RESULTS: aPKCλ/ι overexpression was observed in 36.8% of cases. aPKCλ/ι expression was more intense in poorly differentiated OSCC and younger patients (<60 years of age). Although expression of aPKCλ/ι was not significantly associated with clinical parameters, the correlation was found between aPKCλ/ι localization and progression-free survival. CONCLUSION: This is the first study to assess the association of aPKCλ/ι expression in OSCC with clinical results. Expression and localization of aPKCλ/ι may be involved in the degree of malignancy in OSCC. |
DOI | 10.21873/anticanres.12985 |
PMID | 30396949 |