ナガシマ ヨウジ   Nagashima, Yoji
  長嶋 洋治
   所属   医学部 医学科(東京女子医科大学病院)
   職種   教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Atypical protein kinase C λ/ι expression is associated with malignancy of oral squamous cell carcinoma.
掲載誌名 正式名:Anticancer research
略  称:Anticancer Res
ISSNコード:02507005/17917530
掲載区分国外
巻・号・頁 38(11),6291-6297頁
著者・共著者 Baba J†, Kioi M*, Akimoto K, Nagashma Y, Taguri M, Inayama Y, Aoki I, Ohno S, Mitsudo K, Tohnai I
発行年月 2018/11
概要 BACKGROUND/AIM: Atypical protein kinase C λ/ι (aPKCλ/ι) is a cell
polarity-regulator localized in the tight junction and apical membrane in
epithelial cells. Previous studies suggested that aPKCλ/ι overexpression and
abnormal localization were involved in tumor progression in several cancers. We
investigated the relationship between aPKCλ/ι and oral squamous cell carcinoma
(OSCC).
MATERIALS AND METHODS: The correlation between the aPKCλ/ι expression and the
clinicopathological parameters in 76 OSCC cases was examined using
immunohistochemical analyses.
RESULTS: aPKCλ/ι overexpression was observed in 36.8% of cases. aPKCλ/ι
expression was more intense in poorly differentiated OSCC and younger patients
(<60 years of age). Although expression of aPKCλ/ι was not significantly
associated with clinical parameters, the correlation was found between aPKCλ/ι
localization and progression-free survival.
CONCLUSION: This is the first study to assess the association of aPKCλ/ι
expression in OSCC with clinical results. Expression and localization of aPKCλ/ι
may be involved in the degree of malignancy in OSCC.
DOI 10.21873/anticanres.12985
PMID 30396949