Nagashima, Yoji    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Review article
Language	Japanese
Peer review	Peer reviewed
Presence of invitation	Invited paper
Title	Pathological Classification of Renal Cell Carcinoma, based on WHO2016 Classification
Domestic / Foregin	Domestic
Volume, Issue, Page	pp.1427-1438
Author and coauthor	Yoji Nagashima, Aya Yamamoto, Reiko Nakajima, Satoru Morita, Hironori Fukuda, Toshio Takagi, Tsunenori Kondo
Authorship	Lead author,Corresponding author
Publication date	2017/12
Summary	Pathological classification of renal cell carcinomas (RCCs) has been altered with the impact of novel facts in molecular biology. The WHO2016 classification of RCCs includes the revisions as follows; 1) multilocular cystic RCC has been changed to multilocular cystic neoplasm with low malignant potential, 2)MiT translocation RCC has been introduced encompassing Xp11.2 and 6p21 translocation cases, 3) acquired cystic disease-associated RCC has been introduced as a hemodialysis-related type, 4) several other novel types have been introduced, i.e. clear cell papillary, tubulocystic, succinate dehydrogenase-deficient, hereditary leiomyomatosis RCC-associated, 5) renal medullary carcinoma and post-neuroblastoma RCC were deleted, and 6) novel nuclear grading system based on nucleolar size is recommended to apply to clear cell and papillary RCCs. In this review, we have presented general features of pathological diagnosis of RCCs and novel histological types.