ICHIHARA Atsuhiro    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma.
Journal	Formal name：Scientific reports Abbreviation：Sci Rep ISSN code：20452322
Volume, Issue, Page	5,pp.8854
Author and coauthor	SHIBAYAMA Yuki†, FUJIMORI Takayuki, Genevieve Nguyen, HIROSE Takuo, TOTSUNE Kazuhito, ICHIHARA Atsuhiro, KITADA Kento, NAKANO Daisuke, KOBORI Hiroyuki, KOHNO Masakazu, MASAKI Tsutomu, SUZUKI Yasuyuki, YACHIDA Shinichi, NISHIYAMA Akira
Publication date	2015/03
Summary	Although Wnt/β-catenin signaling is known to be aberrantly activated in PDAC, mutations of CTNNB1, APC or other pathway components are rare in this tumor type, suggesting alternative mechanisms for Wnt/β-catenin activation. Recent studies have implicated the (pro)renin receptor ((P)RR) is related to the Wnt/β-catenin signaling pathway. We therefore investigated the possible role of (P)RR in pancreatic carcinogenesis. Plasma s(P)RR levels were significantly (P<0.0001) higher in patients with PDAC than in healthy matched controls. We also identified aberrant expression of (P)RR in premalignant PanIN and PDAC lesions and all the PDAC cell lines examined. Inhibiting (P)RR with an siRNA attenuated activation of Wnt/β-catenin signaling pathway and reduced the proliferative ability of PDAC cells in vitro and the growth of engrafted tumors in vivo. Loss of (P)RR induced apoptosis of human PDAC cells. This is the first demonstration that (P)RR may be profoundly involved in ductal tumorigenesis in the pancreas.
DOI	10.1038/srep08854
PMID	25747895