ICHIHARA Atsuhiro    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Serum level of soluble (pro)renin receptor is modulated in chronic kidney disease.
Journal	Formal name：Clinical and experimental nephrology Abbreviation：Clin Exp Nephrol ISSN code：1437-7799(Electronic)1342-1751(Linking)
Volume, Issue, Page	17(6),pp.848-56
Author and coauthor	HAMADA Kazu, TANIGUCHI Yoshinori, SHIMAMURA Yoshiko, INOUE Kosuke, OGATA Koji, ISHIHARA Masayuki, HORINO Taro, FUJIMOTO Shimpei, OHGURO Takashi, YOSHIMOTO Yukio, IKEBE Mika, YUASA Kenji, HOSHINO Eri, IIYAMA Tatsuo, ICHIHARA Atsuhiro, TERADA Yoshio
Publication date	2013/12
Summary	BACKGROUND:Prorenin, the precursor of renin, binds to the (pro)renin receptor [(P)RRBACKGROUND:]BACKGROUND:and triggers intracellular signaling. The ligand binding sites of (P)RR are disconnected and are present in the soluble form of the receptor in serum. Given that the clinical significance of serum prorenin and soluble (P)RR in chronic kidney disease (CKD) is unclear, we investigated the relationship between serum prorenin, soluble (P)RR, and various clinical parameters in patients with CKD.METHODS:A total of 374 patients with CKD were enrolled. Serum samples were collected, and the levels of soluble (P)RR and prorenin were measured using ELISA kits. Serum creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA), hemoglobin (Hb), soluble secreted α-Klotho, and the urine protein/Cr ratio were also measured.
DOI	10.1007/s10157-013-0803-y
Document No.	23564382