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ICHIHARA Atsuhiro
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Significant roles of the (pro)renin receptor in integrity of vascular smooth muscle cells. |
| Journal | Formal name：Hypertension research : official journal of the Japanese Society of Hypertension Abbreviation：Hypertens Res ISSN code：13484214(Electronic)09169636(Linking) |
| Volume, Issue, Page | 37(9),pp.830-5 |
| Author and coauthor | KURAUCHI-MITO Asako†, ICHIHARA Atsuhiro*, BOKUDA Kanako, SAKODA Mariyo, KINOUCHI Kenichiro, YAGUCHI Tomonori, YAMADA Taketo, SUN-WADA Ge-Hong, WADA Yoh, ITOH Hiroshi |
| Authorship | Corresponding author |
| Publication date | 2014/05 |
| Summary | UNLABELLED:The (pro)renin receptor ((P)RR) is known to play an important role in the pathogenesis of vascular complications in diabetes mellitus and hypertension through its function in activating the local renin-angiotensin system. Recent studies have shown that the (P)RR is an accessory protein of the vacuolar H(+)-ATPase, suggesting a more fundamental and developmental function. In this study, smooth muscle cell-specific (P)RR/Atp6ap2 conditional knockout mice were generated. Smooth muscle cell-specific ablation of the (P)RR resulted in nonatherogenic sclerosis in the abdominal aorta. The deletion of the (P)RR did not affect ambulatory blood pressure levels. In cultured murine vascUNLABELLED:ular smooth muscle cells (VSMCs), ablation of the (P)RR suppressed the expression of the Vo subunit c of the vacuolar H(+)-ATPase and impaired the cell recycling system, leading to autophagic cell death. In addition, loss of the (P)RR in VSMCs induced the expression of monocyte chemotactic protein-1 and interleukin-6 mRNAs. These results suggest that the (P)RR is essential for cell survival and downregulation of vascular inflammation in murine VSMCs through maintaining normal function of the vacuolar H(+)-ATPase.Hypertension Research advance online publication, 15 May 2014; doi:10.1038/hr.2014.92. |
| DOI | 10.1038/hr.2014.92 |
| PMID | 24830537 |