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KIKUCHI Ken
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | The efficacy of neutralizing monoclonal antibodies in transplant recipients with mild-to-moderate COVID-19. |
| Journal | Formal name：Transplant immunology Abbreviation：Transpl Immunol ISSN code：18785492/09663274 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 77,pp.101777 |
| Author and coauthor | ARIMURA Ken, TAGAYA Etsuko, KIKUCHI Ken, MITSUDA Toshihiro, EBIHARA Fumiya, MARUYAMA Takumi, HAMADA Yukihiro, UNAGAMI Kohei, KANAZAWA Taichi, SEKIGUCHI Haruki, SHIMAMOTO Ken, ISHIDA Hideki, EGAWA Hiroto, TANAKA Junji, KAWANA Masatoshi |
| Publication date | 2023/04 |
| Summary | INTRODUCTION:Transplant recipients (TRs) are at high risk for severe coronavirus disease 2019 (COVID-19). Neutralizing monoclonal antibodies (mAbs) are used for treating mild-to-moderate COVID-19. However, reports comparing the efficacy of COVID-19 treatment without/with mAbs in TRs are limited. We assessed the efficacy of casirivimab/imdevimab against mild-to-moderate COVID-19 in TRs.METHODS:Forty-one patients were retrospectively evaluated. The duration until defervescence, oxygen (O2) requirement ≥5 L, and neutralizing antibody levels were compared in TRs with COVID-19 without/with casirivimab/imdevimab.RESULTS:Casirivimab/imdevimab was correlated with shorter duration until defervescence and non-requirement of O2 ≥ 5 L in TRs with COVID-19 [mean: without/with: 6 vs. 2; P = 0.0002, hazard ratio (HR) = 0.3333, 95% confidence interval (CI) = 0.1763-0.6301; 15 vs. 8; P < 0.0001, HR = 0.5333, 95% CI = 0.2878-0.9883; P = 0.0377, HR = 0.1502, 95% CI = 0.02511-0.8980]. Casirivimab/imdevimab was associated with early defervescence after adjusting for sex and age (P = 0.013, HR = 0.412, 95% CI = 0.205-0.826). The antibody levels between patients without/with casirivimab/imdevimab on the day of hospitalization were not significantly different (P = 0.1055), including 13 TRs with vaccination. Antibody levels were higher in patients with casirivimab/imdevimab at 3-5 days after hospitalization than in those without, at 7-9 days after hospitalization (P < 0.0001, mean, without/with: 414.9/40000 AU/mL).CONCLUSION:Casirivimab/imdevimab was effective and increased the neutralizing antibody in TRs with mild-to-moderate COVID-19, it may contribute toward preventing the progression. |
| DOI | 10.1016/j.trim.2022.101777 |
| PMID | 36584927 |