キクチ ケン   Kikuchi Ken
  菊池 賢
   所属   医学部 医学科(東京女子医科大学病院)
   職種   教授
論文種別 総説
言語種別 英語
査読の有無 査読有り
招待の有無 招待あり
表題 Translational applications of diagnostics of infectious diseases using infectomics approaches in clinical settings.
掲載誌名 正式名:Journal of Bacteriology and Mycology Open Access
略  称:J Bacteriol Mycol Open Access
掲載区分国外
巻・号・頁 00071.頁
著者・共著者 Yoshida Atsushi, Iguchi Shigekazu, Uzawa Yutaka, Kikuchi Ken*
発行年月 2016
概要 Modern molecular and biochemical technologies like polymerase chain reaction (PCR), matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), or microarray, evolved the diagnostic strategies of infectious diseases and changed the routine workflow in clinical microbiology laboratories. However, we still cannot identify causative organisms of many infectious diseases, like febrile neutropenia, sepsis, pneumonia, systemic mycoses and culture-negative endocarditis, in critically ill patients even though using such molecular techniques, and consequently we use antimicrobials or antifungals empirically for these cases without any evidence of pathogens specified. Now we need to find out the alternative way for diagnostics of infectious diseases. In the post-genomics era, undiagnosed infectious diseases would be analyzed by comprehensive data mining and hierarchical algorithm obtained from perspective infectome that analyzes host-pathogen-microbiome interactions. Accordingly we require a new translational application in clinical settings from this infectomics. Detecting pathogen-specific or infected host-derived volatile organic compounds is one of the good answers because it is non-invasive, easily performed, rapid, inexpensive, and available for point-of-care testing for diagnosis of infectious diseases. This mini-review focuses unmet needs of diagnostics of infectious diseases in clinical settings and impact of alternative diagnostic ways using infectomics approaches and their clinical implications.
DOI 10.15406/jbmoa.2016.03.00071