セキネ　ヤスオ   SEKINE YASUO   関根　康雄    所属   医学部 医学科（附属八千代医療センター）    職種   客員教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	EGFR mutation of adenocarcinoma in congenital cystic adenomatoid malformation/congenital pulmonary airway malformation: a case report.
掲載誌名	正式名：Japanese journal of clinical oncology 略　 称：Jpn J Clin Oncol ISSNコード：(1465-3621)0368-2811(Linking)
巻・号・頁	44(3),pp.278-81
著者・共著者	Hasegawa Mizue†*, Sakai Fumikazu, Arimura Ken, Katsura Hideki, Koh Eitetsu, Sekine Yasuo, Hiroshima Kenzo
発行年月	2014/03
概要	An 80-year-old man underwent right upper lobectomy for the resection of multiple cysts accompanied by a nodule. The pathological diagnosis was adenocarcinoma with surrounding atypical epithelial cell proliferation in a Type 1 congenital cystic adenomatoid malformation/congenital pulmonary airway malformation. There was epidermal growth factor receptor mutation in the adenocarcinoma and surrounding atypical epithelial cells that had proliferated. Malignant transformation of congenital cystic adenomatoid malformation/congenital pulmonary airway malformation may be related to the epidermal growth factor receptor pathway in this case, with atypical epithelial cell proliferation as a precursor. We emphasize the importance of complete resection of congenital cystic adenomatoid malformation/congenital pulmonary airway malformation and the possibility of treatment with epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor-mutated cases.
DOI	10.1093/jjco/hyt226
PMID	24482415