TABATA Tsutomu
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor and Division head
Article types Original article
Language English
Peer review Peer reviewed
Presence of invitation Invited paper
Title Trends in Pregnancy-Associated Cervical Cancer in Japan between 2012 and 2017: A Multicenter Survey.
Journal Formal name：Cancers
Abbreviation：Cancers (Basel)
ISSN code：20726694/20726694
Domestic / ForeginDomestic
Volume, Issue, Page 14(13),pp.1-13
Author and coauthor Enomoto Sayako, Yoshihara Kosuke, Kondo Eiji, Iwata Akiko, Tanaka Mamoru, Tabata Tsutomu, Kudo Yoshiki, Kondoh Eiji, Mandai Masaki, Sugiyama Takashi, Okamoto Aikou, Saito Tsuyoshi, Enomoto Takayuki, Ikeda Tomoaki
Authorship Corresponding author
Publication date 2022/06
Summary Large-scale data on maternal and neonatal outcomes of pregnancy-associated cervical cancer in Japan are scarce, and treatment strategies have not been established. This multicenter retrospective observational study investigated clinical features and trends in pregnancy-associated cervical cancer treatments at 523 hospitals in Japan. We included cervical cancer cases that were histologically diagnosed (between 1 January 2012, and 31 December 2017), and their clinical information was retrospectively collected. Of 40 patients diagnosed with pregnancy-associated cervical cancer at ≥22 gestational weeks, 34 (85.0%) were carefully followed until delivery without intervention. Of 163 diagnosed at <22 gestational weeks, 111 continued and 52 terminated their pregnancy. Ninety patients with stage IB1 disease had various treatment options, including termination of pregnancy. The 59 stage IB1 patients who continued their pregnancy were categorized by the primary treatment into strict follow-up, conization, trachelectomy, and neoadjuvant chemotherapy groups, with no significant differences in progression-free or overall survival. The birth weight percentile at delivery was smaller in the neoadjuvant chemotherapy group than in the strict follow-up group (p = 0.029). Full-term delivery rate was relatively higher in the trachelectomy group (35%) than in the other groups. Treatment decisions for pregnancy-associated cervical cancer are needed after estimating the stage, considering both maternal and fetal benefits.
DOI 10.3390/cancers14133072
PMID 35804845