NAKAMURA Shinichi
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Prevalence of Gastric Non-Helicobacter pylori-Helicobacters in Japanese Patients with Gastric Disease.
Journal Formal name：Digestion
Abbreviation：Digestion
ISSN code：14219867/00122823
Domestic / ForeginForegin
Volume, Issue, Page 95(1),pp.61-66
Author and coauthor Øverby Anders, Murayama Somay Y, Michimae Hirofumi, Suzuki Hidekazu, Suzuki Masayuki, Serizawa Hiroshi, Tamura Ryo, Nakamura Shinichi, Takahashi Shinichi, Nakamura Masahiko
Publication date 2017
Summary BACKGROUND:Non-Helicobacter pylori-helicobacters (NHPH) compose a group of gram negative zoonotic bacteria that may induce in humans gastric diseases including gastritis, gastroduodenal ulcer and MALT lymphoma. Their prevalence in the general population has previously been reported to 0.1-6.2%, although such reports still remain less in number.AIMS:This study aimed at estimating the prevalence of gastric NHPH in Japanese people, and further aimed at linking this to different gastric diseases and co-infection with H. pylori.METHODS:Endoscopically obtained biopsy samples from 280 Japanese patients with various gastric diseases were collected. Samples were analyzed by immunohistochemistry and by species-specific PCR for detection of gastric helicobacters.RESULTS:The total prevalence of gastric NHPH among 280 Japanese patients was 6.1%, and the prevalence of H. pylori was 65.7%. There was no significant difference in prevalence of either NHPH or H. pylori when infected with H. pylori or NHPH, respectively. NHPH infection was found to be the highest in patients with gastric MALT lymphoma and duodenal ulcer, the former being independent of co-infection with H. pylori and the latter being dependent.CONCLUSIONS:This study reports a total prevalence of 6.1% of gastric NHPH in Japanese patients, and further highlights gastric MALT lymphoma and duodenal ulcer (when co-infected with H. pylori) as important related diseases.
DOI 10.1159/000452400
PMID 28052279