NAKAMURA Shinichi    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor
Article types	Original article
Language	English
Peer review	Non peer reviewed
Title	Effects of rikkunshito on quality of life in patients with gastroesophageal reflux disease refractory to proton pump inhibitor therapy.
Journal	Formal name：Journal of clinical biochemistry and nutrition Abbreviation：J Clin Biochem Nutr ISSN code：09120009/09120009
Volume, Issue, Page	60(2),pp.143-145
Author and coauthor	Kawai Takashi, Hirayama Yoji, Oguchi Aiko, Ishii Fumi, Matushita Masanao, Kitayama Naoya, Morishita Shinji, Hiratsuka Noboru, Ohata Ken, Konishi Hiroyuki, Kishino Maiko, Nakamura Shinichi
Authorship	Last author
Publication date	2017/03
Summary	We investigated the effects of rikkunshito, in combination with a proton pump inhibitor, on symptoms and quality of life in patients with proton pump inhibitor-refractory gastroesophageal reflux disease. The subjects were 47 patients with gastroesophageal reflux disease with residual symptoms such as heartburn following 8 weeks of proton pump inhibitor therapy. We administered these subjects rikkunshito in combination with a proton pump inhibitor for 6-8 weeks. We scored their symptoms of heartburn, fullness, abdominal discomfort, and abdominal pain, and surveyed their quality of life using the Reflux Esophagitis Symptom Questionnaire, comprising questions concerning daily activities, meals (changes in amount and favorite foods), and sleep (getting to sleep and early morning waking). Improvement was seen in all symptoms, and quality of life scores for meals and sleep also improved. These results indicate that combination therapy with rikkunshito and a proton pump inhibitor improves quality of life related to eating and sleep in patients with patients with proton pump inhibitor-refractory gastroesophageal reflux disease.
DOI	10.3164/jcbn.16-77
PMID	28366995