ナカムラ　シンイチ   NAKAMURA Shinichi   中村　真一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Effects of rikkunshito on quality of life in patients with gastroesophageal reflux disease refractory to proton pump inhibitor therapy.
掲載誌名	正式名：Journal of clinical biochemistry and nutrition 略　 称：J Clin Biochem Nutr ISSNコード：09120009/09120009
巻・号・頁	60(2),pp.143-145
著者・共著者	Kawai Takashi, Hirayama Yoji, Oguchi Aiko, Ishii Fumi, Matushita Masanao, Kitayama Naoya, Morishita Shinji, Hiratsuka Noboru, Ohata Ken, Konishi Hiroyuki, Kishino Maiko, Nakamura Shinichi
担当区分	最終著者
発行年月	2017/03
概要	We investigated the effects of rikkunshito, in combination with a proton pump inhibitor, on symptoms and quality of life in patients with proton pump inhibitor-refractory gastroesophageal reflux disease. The subjects were 47 patients with gastroesophageal reflux disease with residual symptoms such as heartburn following 8 weeks of proton pump inhibitor therapy. We administered these subjects rikkunshito in combination with a proton pump inhibitor for 6-8 weeks. We scored their symptoms of heartburn, fullness, abdominal discomfort, and abdominal pain, and surveyed their quality of life using the Reflux Esophagitis Symptom Questionnaire, comprising questions concerning daily activities, meals (changes in amount and favorite foods), and sleep (getting to sleep and early morning waking). Improvement was seen in all symptoms, and quality of life scores for meals and sleep also improved. These results indicate that combination therapy with rikkunshito and a proton pump inhibitor improves quality of life related to eating and sleep in patients with patients with proton pump inhibitor-refractory gastroesophageal reflux disease.
DOI	10.3164/jcbn.16-77
PMID	28366995