シガ　ツヨシ   Tsuyoshi Shiga   志賀　剛    所属   医学部 医学科（東京女子医科大学病院）    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Different chronotherapeutic effects of valsartan and olmesartan in non-dipper hypertensive patients during valsartan treatment at morning.
掲載誌名	正式名：Journal of pharmacological sciences 略　 称：J Pharmacol Sci ISSNコード：13478613/13478648
掲載区分	国内
出版社	Japanese Pharmacological Society
巻・号・頁	127(1),pp.62-68
著者・共著者	USHIJIMA Kentaro†, NAKASHIMA Hajime, SHIGA Tsuyoshi, HARADA Kazuhiro, ISHIKAWA Shizukiyo, IOKA Takashi, ANDO Hitoshi, FUJIMURA Akio
発行年月	2015/01
概要	This study was undertaken to evaluate the differences in chronotherapeutic effects of angiotensin-II receptor blockers, valsartan and olmesartan in hypertensive patients with non-dipper blood pressure (BP) pattern during valsartan at morning. Ninety four patients were enrolled, and 40 patients were judged to be non-dippers. In these patients, same dose of valsartan was changed to evening (Val-E, n = 12), or olmesartan (equivalent dose of valsartan) was given at morning (Olm-M, n = 13) or evening (Olm-E, n = 15) for 4 months. BP decreased during sleep and increased during waking hours in Val-E group. In Olm-M and Olm-E groups, BP decreased during sleep and waking hours. Percent reduction in BP at night-time compared to BP at waking hours significantly increased after changing the dose regimen in each group. Serum creatinine decreased and estimated glomerular filtration rate (eGFR) elevated in Olm-M and Olm-E, but not Val-E groups. Positive correlation between systolic BP (SBP) during sleep and serum creatinine, and negative correlation between SBP during sleep and eGFR were detected. These data suggest that dipper BP pattern could be obtained by chronotherapeutic approach using valsartan and olmesartan in non-dipper patients with valsartan at morning. Morning and evening olmesartan, but not evening valsartan improved renal function in these patients.
DOI	10.1016/j.jphs.2014.09.004
PMID	25704020