川口　鎮司    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Clinical Professor
Article types	Original article
Language	English
Peer review	Non peer reviewed
Title	Genetic Susceptibility to Interstitial Lung Disease Associated with Systemic Sclerosis.
Journal	Formal name：Clinical medicine insights. Circulatory, respiratory and pulmonary medicine Abbreviation：Clin Med Insights Circ Respir Pulm Med ISSN code：(1179-5484)1179-5484(Linking)
Domestic / Foregin	Foregin
Volume, Issue, Page	9(Suppl 1),pp.135-40
Author and coauthor	Tochimoto Akiko†, Kawaguchi Yasushi*, Yamanaka Hisashi
Authorship	Corresponding author
Publication date	2015
Summary	Systemic sclerosis (SSc) is a connective tissue disease that is characterized by tissue fibrosis, microvasculopathy, and autoimmunity. Interstitial lung disease (ILD) is a common complication of SSc and is one of the frequent causes of mortality in SSc. Although the exact etiology of SSc remains unknown, clinical and experimental investigations have suggested that genetic and environmental factors are relevant to the pathogenesis of SSc and SSc-ILD. More than 30 genes have been identified as susceptibility loci for SSc, most of which are involved in immune regulation and inflammation. It is thought that the key pathogenesis of SSc-ILD is caused by the release of profibrotic mediators such as transforming growth factor β1 and connective tissue growth factor from lung cells induced by a persistent damage. This review presents the genetic susceptibility to SSc-ILD, including human leukocyte antigen and non-human leukocyte antigen genes, especially focusing on connective tissue growth factor.
DOI	10.4137/CCRPM.S23312
PMID	26997879