カワグチ　ヤスシ   川口　鎮司    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Interstitial Lung Disease with ANCA-associated Vasculitis.
掲載誌名	正式名：Clinical medicine insights. Circulatory, respiratory and pulmonary medicine 略　 称：Clin Med Insights Circ Respir Pulm Med ISSNコード：(1179-5484)1179-5484(Linking)
掲載区分	国外
巻・号・頁	9(Suppl 1),pp.51-6
著者・共著者	Katsumata Yasuhiro†, Kawaguchi Yasushi*, Yamanaka Hisashi
担当区分	責任著者
発行年月	2015
概要	The association between interstitial lung disease (ILD) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), particularly microscopic polyangiitis (MPA), has been described in a number of case reports and case series reports in the last 2 decades. In addition, patients with pulmonary fibrosis and ANCA positivity but without other manifestations of systemic vasculitis have also been reported. Pulmonary fibrosis was clinically manifested at the time of diagnosis in the majority of AAV patients that developed this condition. Moreover, ANCA-positive conversion occurs in patients initially diagnosed with idiopathic pulmonary fibrosis, and as a result, other manifestations of systemic vasculitis develop in some of these patients. There is significant predominance of myeloperoxidase (MPO)-ANCA and MPA in patients with AAV and ILD. Radiological and pathological findings generally demonstrate usual interstitial pneumonia (pattern) in the lungs of these patients. In most studies, AAV patients with ILD have a worse prognosis than those without it.
DOI	10.4137/CCRPM.S23314
PMID	26448696