ミツイシ ツヨシ
  三石 剛
   所属   医学部 医学科(附属八千代医療センター)
   職種   准教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Two sisters reveal autosomal recessive inheritance of epidermodysplasia verruciformis: a case report.
掲載誌名 正式名:BMC dermatology
略  称:BMC Dermatol
ISSNコード:1471594514715945
掲載区分国外
巻・号・頁 14,12頁
著者・共著者 Yoshida Rui, Kato Toshihiko, Kawase Masahiko, Honda Mariko, Mitsuishi Tsuyoshi
発行年月 2014/07
概要 BACKGROUND:Epidermodysplasia verruciformis is a rare genodermatosis characterized by a unique susceptibility to cutaneous human papillomaviruses infection. Most patients show autosomal recessive patterns of inheritance.CASE PRESENTATION:We report a case of two sisters with clinically epidermodysplasia verruciformis specific lesions on the face, neck, trunk, and extremities. PCR analysis indicated the presence of human papillomavirus type 5 in the lesions. Electron microscopic examination showed viral-like particles in keratinocyte nuclei and the stratum corneum of the epidermodysplasia verruciformis lesions. In addition, we examined the EVER1 and EVER2 genes using eight different primer pairs without finding any nonsense or frameshift mutations in the gDNA from lymphocytes of the elder sister.CONCLUSIONS:In this report, the patient's parents did not have epidermodysplasia verruciformis lesions or a consanguineous marriage. EV did not develop in the elder sister until five years of age, so the parents did not perceive EV as an inherited disease. The probability that EV developed in both sisters was only 6.25%. Thus, it is rare for both sisters to develop epidermodysplasia verruciformis lesions considering that the parents were presumed to be carriers and the disease reveal an autosomal recessive pattern of inheritance.
DOI 10.1186/1471-5945-14-12
PMID 25048734