Department   School of Medicine, School of Medicine
   Position   Professor and Division head
Article types Original article
Language English
Peer review Peer reviewed
Title Quantification of Methamphetamine in Mouse Thighbones Buried in Soil.
Journal Formal name:Journal of forensic sciences
Abbreviation:J Forensic Sci
ISSN code:(1556-4029)0022-1198(Linking)
Domestic / ForeginForegin
Volume, Issue, Page 62(6),pp.1154-1158
Author and coauthor Nakao Ken-ichiro†*, Tatara Yuki, Kibayashi Kazuhiko
Authorship Last author
Publication date 2017/04
Summary Bone samples are used for analysis of drugs in decomposed or skeletonized bodies. Toxicological analyses of buried bones are important for determining the causes and circumstances of death. In this study, methamphetamine and amphetamine concentrations in heart blood, thigh muscles, and thighbones were analyzed using solid-phase extraction with liquid chromatography-tandem mass spectrometry. Methamphetamine concentrations in heart blood, thigh muscle, and thighbone ranged from 0.041 to 0.873 μg/mL, 0.649 to 2.623 μg/g, and 56.543 to 643.371 μg/g, respectively. Thighbone concentrations were significantly higher than those in heart blood or thigh muscles were. Methamphetamine concentrations in buried thighbone (4.010-45.785 μg/g) were significantly lower than those of unburied thighbones were (56.543-643.371 μg/g). Methamphetamine and amphetamine were detected in thighbones buried for 7-180 days. These findings indicate that the methamphetamine concentrations in bone are higher and decrease after burial in soil.
DOI 10.1111/1556-4029.13458
PMID 28436031