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Fumio Nakamura
Department School of Medicine, School of Medicine Position Professor and Division head |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Immunoreactivity of a G protein-coupled l-DOPA receptor GPR143, in Lewy bodies. |
| Journal | Formal name：Neuroscience research Abbreviation：Neurosci Res ISSN code：18728111/01680102 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 148,pp.49-53 |
| Author and coauthor | Goshima Yoshio, Watanabe Shuya, Seki Erika, Koga Motokazu, Masukawa Daiki, Nakamura Fumio, Komori Takashi, Arai Nobutaka |
| Publication date | 2019/11 |
| Summary | l-3,4-Dihydroxyphenylalanine (l-DOPA) has been believed to be an inert amino acid precursor of dopamine, and is the most effective therapeutic agent in Parkinson's disease (PD). We proposed l-DOPA as a neurotransmitter in the central nervous system. Recently, the ocular albinism 1 gene product, OA1/GPR143 (GPR143), was identified as a receptor for l-DOPA. In this study, we examined by generating anti-human GPR143 antibody, the localization of GPR143-immunoreactive signals in the brains from control and PD subjects. GPR143-immunoreactive signals were detected throughout the entire midbrain including substantia nigra pars compacta. In the PD brains, we found that GPR143-immunoreactive signals were detected in Lewy bodies and were colocalized with immunoreactive signals with anti-human Ser129 phosphorylated α-synuclein antibody. Although the significance of its occurrence in the inclusion bodies is unknown, our finding suggests possible implications of GPR143 in PD. |
| DOI | 10.1016/j.neures.2018.12.004 |
| PMID | 30590075 |