シセキ マサユキ   SHISEKI Masayuki
  志関 雅幸
   所属   医学部 医学科(東京女子医科大学病院)
   職種   准教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Expression analysis of genes located within the common deleted region of del(20q) in patients with myelodysplastic syndromes.
掲載誌名 正式名:Leukemia research
略  称:Leuk Res
ISSNコード:18735835/01452126
掲載区分国外
巻・号・頁 84,pp.106175
著者・共著者 Shiseki Masayuki†*, Ishii Mayuko, Okada Michiko, Ohwashi Mari, Wang Yan-Hua, Osanai Satoko, Yoshinaga Kentaro, Mori Naoki, Motoji Toshiko, Tanaka Junji
担当区分 筆頭著者,責任著者
発行年月 2019/09
概要 Deletion of the long arm of chromosome 20 (del(20q)) is observed in 5-10% of patients with myelodysplastic syndromes (MDS). We examined the expression of 28 genes within the common deleted region (CDR) of del(20q), which we previously determined by a CGH array using clinical samples, in 48 MDS patients with (n = 28) or without (n = 20) chromosome 20 abnormalities and control subjects (n = 10). The expression level of 8 of 28 genes was significantly reduced in MDS patients with chromosome 20 abnormalities compared to that of control subjects. In addition, the expression of BCAS4, ADA, and YWHAB genes was significantly reduced in MDS patients without chromosome 20 abnormalities, which suggests that these three genes were commonly involved in the molecular pathogenesis of MDS. To evaluate the clinical significance, we analyzed the impact of the expression level of each gene on overall survival (OS). According to the Cox proportional hazard model, multivariate analysis indicated that reduced BCAS4 expression was associated with inferior OS, but the difference was not significant (HR, 3.77; 95% CI, 0.995-17.17; P = 0.0509). Functional analyses are needed to understand the biological significance of reduced expression of these genes in the pathogenesis of MDS.
DOI 10.1016/j.leukres.2019.106175
PMID 31299412