サイトウ　サトシ   SAITO Satoshi   齋藤　聡    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Chronic nonpulsatile blood flow is compatible with normal end-organ function: implications for LVAD development.
掲載誌名	正式名：Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 略　 称：J Artif Organs ISSNコード：14347229/1434-7229
掲載区分	国内
巻・号・頁	8(3),pp.143-148
著者・共著者	SAITO Satoshi†, NISHINAKA Tomohiro
発行年月	2005
概要	Evolving blood pump technology has produced user-friendly continuous-flow left ventricular assist devices, but uncertainty exists about the safety of chronic nonpulsatile circulation. Recent experimental and clinical evidence suggest that pulse pressure is not required from a blood pump. End-organ function is well maintained with nonpulsatile systems, although pulse pressure may accelerate recovery from cardiogenic shock. Form follows function, so the effects of reduced pulse pressure on the arterial wall are not surprising. The ability to alter aortic wall morphology by reducing pulse pressure may have important implications for the future treatment of arterial pathology. Both centrifugal and axial-flow pumps can be miniaturized and are reliable and silent. Doubts about the feasibility of long-term circulation with reduced pulse pressure are disappearing.
DOI	10.1007/s10047-005-0295-y
PMID	16235030