ONO Masafumi
   Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine
Article types Original article
Language English
Peer review Peer reviewed
Title A Data Mining-based Prognostic Algorithm for NAFLD-related Hepatoma Patients: A Nationwide Study by the Japan Study Group of NAFLD.
Journal Formal name:Scientific reports
Abbreviation:Sci Rep
ISSN code:20452322/20452322
Domestic / ForeginForegin
Volume, Issue, Page 8(1),pp.10434
Author and coauthor Kawaguchi Takumi, Tokushige Katsutoshi, Hyogo Hideyuki, Aikata Hiroshi, Nakajima Tomoaki, Ono Masafumi, Kawanaka Miwa, Sawada Koji, Imajo Kento, Honda Koichi, Takahashi Hirokazu, Mori Kohjiroh, Tanaka Saiyu, Seko Yuya, Nozaki Yuichi, Kamada Yoshihiro, Fujii Hideki, Kawaguchi Atsushi, Takehara Tetsuo, Yanase Mikio, Sumida Yoshio, Eguchi Yuichiro, Seike Masataka, Yoneda Masato, Suzuki Yasuaki, Saibara Toshiji, Karino Yoshiyasu, Chayama Kazuaki, Hashimoto Etsuko, George Jacob, Torimura Takuji
Publication date 2018/07
Summary The prognosis of patients with nonalcoholic fatty liver disease-related hepatocellular carcinoma (NAFLD-HCC) is intricately associated with various factors. We aimed to investigate the prognostic algorithm of NAFLD-HCC patients using a data-mining analysis. A total of 247 NAFLD-HCC patients diagnosed from 2000 to 2014 were registered from 17 medical institutions in Japan. Of these, 136 patients remained alive (Alive group) and 111 patients had died at the censor time point (Deceased group). The random forest analysis demonstrated that treatment for HCC and the serum albumin level were the first and second distinguishing factors between the Alive and Deceased groups. A decision-tree algorithm revealed that the best profile comprised treatment with hepatectomy or radiofrequency ablation and a serum albumin level ≥3.7 g/dL (Group 1). The second-best profile comprised treatment with hepatectomy or radiofrequency ablation and serum albumin levels <3.7 g/dL (Group 2). The 5-year overall survival rate was significantly higher in the Group 1 than in the Group 2. Thus, we demonstrated that curative treatment for HCC and serum albumin level >3.7 g/dL was the best prognostic profile for NAFLD-HCC patients. This novel prognostic algorithm for patients with NAFLD-HCC could be used for clinical management.
DOI 10.1038/s41598-018-28650-0
PMID 29992975