ONO Masafumi
   Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine
   Position  
Article types Original article
Language English
Peer review Peer reviewed
Title Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS.
Journal Formal name：Scientific reports
Abbreviation：Sci Rep
ISSN code：20452322/20452322
Domestic / ForeginForegin
Volume, Issue, Page 7(1),pp.10146
Author and coauthor Ochi Tsunehiro, Kawaguchi Takumi, Nakahara Takashi, Ono Masafumi, Noguchi Shuhei, Koshiyama Yuichi, Munekage Kensuke, Murakami Eisuke, Hiramatsu Akira, Ogasawara Mitsunari, Hirose Akira, Mizuta Hiroshi, Masuda Kosei, Okamoto Nobuto, Suganuma Narufumi, Chayama Kazuaki, Yamaguchi Masahiro, Torimura Takuji, Saibara Toshiji
Publication date 2017/08
Summary Glucose intolerance frequently develops in accordance with the progression of chronic liver disease. However, differences in the characteristics of glucose intolerance between patients with nonalcoholic fatty liver disease (NAFLD) and those with chronic hepatitis C (C-CH) remain incompletely understood. To clarify these differences, patients with NAFLD (n = 37) and C-CH (n = 40) were evaluated with a continuous glucose monitoring system (CGMS). In the patients with NAFLD, Maximum blood glucose concentration and blood glucose swings were significantly correlated with hepatic fibrosis markers. In the patients with C-CH, however, those two CGMS parameters were negatively correlated with the serum albumin (ALB) concentration. Furthermore, in the patients with C-CH with an ALB concentration of ≤4.0 g/dl, those two CGMS parameters were negatively correlated with the ALB concentration with greater statistical significance. In conclusion, obvious differences in the characteristics of glucose intolerance between patients with NAFLD and those with C-CH were clarified. In patients with NAFLD, glucose intolerance gradually progressed in accordance with the progression of hepatic fibrosis. In those with C-CH, glucose intolerance suddenly developed upon the appearance of hypoalbuminaemia.
DOI 10.1038/s41598-017-09256-4
PMID 28860506