オノ　マサフミ   ONO Masafumi   小野　正文    所属   医学部 医学科（附属足立医療センター）    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS.
掲載誌名	正式名：Scientific reports 略　 称：Sci Rep ISSNコード：20452322/20452322
掲載区分	国外
巻・号・頁	7(1),pp.10146
著者・共著者	Ochi Tsunehiro, Kawaguchi Takumi, Nakahara Takashi, Ono Masafumi, Noguchi Shuhei, Koshiyama Yuichi, Munekage Kensuke, Murakami Eisuke, Hiramatsu Akira, Ogasawara Mitsunari, Hirose Akira, Mizuta Hiroshi, Masuda Kosei, Okamoto Nobuto, Suganuma Narufumi, Chayama Kazuaki, Yamaguchi Masahiro, Torimura Takuji, Saibara Toshiji
発行年月	2017/08
概要	Glucose intolerance frequently develops in accordance with the progression of chronic liver disease. However, differences in the characteristics of glucose intolerance between patients with nonalcoholic fatty liver disease (NAFLD) and those with chronic hepatitis C (C-CH) remain incompletely understood. To clarify these differences, patients with NAFLD (n = 37) and C-CH (n = 40) were evaluated with a continuous glucose monitoring system (CGMS). In the patients with NAFLD, Maximum blood glucose concentration and blood glucose swings were significantly correlated with hepatic fibrosis markers. In the patients with C-CH, however, those two CGMS parameters were negatively correlated with the serum albumin (ALB) concentration. Furthermore, in the patients with C-CH with an ALB concentration of ≤4.0 g/dl, those two CGMS parameters were negatively correlated with the ALB concentration with greater statistical significance. In conclusion, obvious differences in the characteristics of glucose intolerance between patients with NAFLD and those with C-CH were clarified. In patients with NAFLD, glucose intolerance gradually progressed in accordance with the progression of hepatic fibrosis. In those with C-CH, glucose intolerance suddenly developed upon the appearance of hypoalbuminaemia.
DOI	10.1038/s41598-017-09256-4
PMID	28860506