ONO Masafumi    Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine    Position
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey.
Journal	Formal name：Journal of gastroenterology Abbreviation：J Gastroenterol ISSN code：14355922/09441174
Domestic / Foregin	Domestic
Volume, Issue, Page	51(6),pp.586-96
Author and coauthor	Tokushige Katsutoshi, Hyogo Hideyuki, Nakajima Tomoaki, Ono Masafumi, Kawaguchi Takumi, Honda Koichi, Eguchi Yuichiro, Nozaki Yuichi, Kawanaka Miwa, Tanaka Saiyu, Imajo Kento, Sumida Yoshio, Kamada Yoshihiro, Fujii Hideki, Suzuki Yasuaki, Kogiso Tomomi, Karino Yoshiyasu, Munekage Kensuke, Kuromatsu Ryoko, Oeda Satoshi, Yanase Mikio, Mori Kohjiro, Ogawa Yuji, Seko Yuya, Takehara Tetsuo, Itoh Yoshito, Nakajima Atsushi, Kanemasa Kazuyuki, Nishino Ken, Masaki Naohiko, Takahashi Hirokazu, Seike Masataka, Torimura Takuji, Saibara Toshiji, Toyota Joji, Chayama Kazuaki, Hashimoto Etsuko
Publication date	2016/06
Summary	BACKGROUND:In Japan, the prevalence of hepatocellular carcinoma (HCC) associated with nonviral liver disease, especially with nonalcoholic fatty liver disease (NAFLD-HCC) and alcoholic liver disease (ALD-HCC), has been increasing. Clarification of the clinical features of NAFLD-HCC and ALD-HCC is needed. We performed a large retrospective multicenter survey to clarify the clinical course of these two types of HCC.METHODS:Clinical characteristics, survival, and recurrence were examined in 532 patients with ALD-HCC and 209 patients with NAFLD-HCC who were diagnosed between January 2000 and December 2013.RESULTS:The ALD-HCC patients were predominantly male and were younger than the patients with NAFLD-HCC. Lifestyle-related diseases were significantly more common in the NAFLD-HCC group, but the prevalence of cirrhosis was significantly higher in the ALD-HCC group. The histological diagnosis of NAFLD-HCC showed a gender difference (F4; 72.7 % in the females vs. 37.6 % in the males). The characteristic features of HCC including histology, survival rate, and recurrence rate were quite similar in the NAFLD-HCC and ALD-HCC groups: 5-year survival rates 49.1 vs. 43.7 %; 5-year recurrence rates 69.6 vs. 65.4 %, respectively. However, the risk factors for recurrence differed between the two groups: des-gamma-carboxy prothrombin was a risk factor in NAFLD-HCC and α-fetoprotein was a risk factor in ALD-HCC.CONCLUSIONS:Although the characteristic features underlying these two diseases are different, the two HCC groups showed a similar clinical course. The recurrence rates of the two HCC groups were relatively high. We found that critical tumor markers for recurrence differed between the two diseases.
DOI	10.1007/s00535-015-1129-1
PMID	26456168