ONO Masafumi
   Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine
   Position  
Article types Original article
Language English
Peer review Peer reviewed
Title Biphasic effect of alcohol intake on the development of fatty liver disease.
Journal Formal name：Journal of gastroenterology
Abbreviation：J Gastroenterol
ISSN code：14355922/09441174
Domestic / ForeginDomestic
Volume, Issue, Page 50(11),pp.1114-23
Author and coauthor Takahashi Hirokazu, Ono Masafumi, Hyogo Hideyuki, Tsuji Chika, Kitajima Yoichiro, Ono Naofumi, Eguchi Takahisa, Fujimoto Kazuma, Chayama Kazuaki, Saibara Toshiji, Anzai Keizo, Eguchi Yuichiro
Publication date 2015/11
Summary BACKGROUND:Fatty liver is an important clinical feature not only in alcoholic and non-alcoholic fatty liver diseases, but in other chronic liver diseases as well. Our aim was to elucidate the effect and relationship between habitual alcohol intake and obesity in the development of fatty liver disease.METHODS:We enrolled 8,029 subjects undergoing abdominal ultrasonography with general medical examinations, and analyzed the factors associated with fatty liver based on daily alcohol intake, body mass index (BMI), and waist circumference.RESULTS:For fatty liver, BMI, waist circumference, total cholesterol, triglycerides, and fasting plasma glucose were significant and independent risk factors. Heavy alcohol intake (50 g/day) was a significant risk factor for fatty liver in women (odds ratio [OR], 3.35). Analysis based on the presence or absence of obesity revealed that moderate alcohol intake was a significant negative risk factor for fatty liver in both male and female obese (BMI ≥25 kg/m(2)) subjects (OR, 0.74 for non-obese and 0.39 for obese patients, respectively). Heavy alcohol intake was also a significant negative risk factor in obese males (0.62). In contrast, heavy alcohol intake was a risk factor in non-obese males (OR, 1.29) and in all females (OR, 2.22 for non-obese and 6.6 for obese patients, respectively).CONCLUSIONS:The influence of alcohol intake on fatty liver differed depending on the level of alcohol consumption, gender, and the presence of obesity, and showed biphasic effects.
DOI 10.1007/s00535-015-1058-z
PMID 25733100