ONO Masafumi
   Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine
Article types Original article
Language English
Peer review Peer reviewed
Title Pilot study of liraglutide effects in non-alcoholic steatohepatitis and non-alcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J).
Journal Formal name:Hepatology research : the official journal of the Japan Society of Hepatology
Abbreviation:Hepatol Res
ISSN code:13866346/13866346
Domestic / ForeginDomestic
Volume, Issue, Page 45(3),pp.269-78
Author and coauthor Eguchi Yuichiro, Kitajima Yoichiro, Hyogo Hideyuki, Takahashi Hirokazu, Kojima Motoyasu, Ono Masafumi, Araki Norimasa, Tanaka Kenichi, Yamaguchi Miyuki, Matsuda Yayoi, Ide Yasushi, Otsuka Taiga, Ozaki Iwata, Ono Naofumi, Eguchi Takahisa, Anzai Keizo,
Publication date 2015/03
Summary AIM:Non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, is associated with an increased risk of developing lifestyle-related diseases including type 2 diabetes, cardiovascular disease and cerebral vessel disease. No current drug therapy provides the ideal effects of decreasing hepatic inflammation while simultaneously improving liver fibrosis. Liraglutide is a glucagon-like peptide-1 receptor agonist that affects the histological findings in patients with non-alcoholic steatohepatitis (NASH). This study was conducted to evaluate the effect and action of liraglutide for biopsy-proven NASH.METHODS:After lifestyle modification intervention for 24 weeks, subjects whose hemoglobin A1c levels failed to improve to less than 6.0% and/or whose alanine aminotransferase levels were not lower than baseline, received liraglutide at 0.9 mg/body per day for 24 weeks.RESULTS:Of 27 subjects, 26 completed the lifestyle modification intervention. Nineteen subjects received liraglutide therapy for 24 weeks. Body mass index, visceral fat accumulation, aminotransferases and glucose abnormalities improved significantly. Repeated liver biopsy was performed in 10 subjects who continued liraglutide therapy for 96 weeks. Six subjects showed decreased histological inflammation as determined by NASH activity score and stage determined by Brunt classification. We saw no significant adverse events during therapy with liraglutide.CONCLUSION:Our pilot study demonstrated that treatment with liraglutide had a good safety profile and significantly improved liver function and histological features in NASH patients with glucose intolerance.
DOI 10.1111/hepr.12351
PMID 24796231