ONO Masafumi
   Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine
Article types Original article
Language English
Peer review Peer reviewed
Title Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease.
Journal Formal name:World journal of gastroenterology
Abbreviation:World J Gastroenterol
ISSN code:22192840/10079327
Domestic / ForeginForegin
Volume, Issue, Page 20(29),pp.10108-14
Author and coauthor Kessoku Takaomi, Ogawa Yuji, Yoneda Masato, Imajo Kento, Sumida Yoshio, Eguchi Yuichiro, Fujii Hideki, Hyogo Hideyuki, Ono Masafumi, Suzuki Yasuaki, Kawaguchi Takumi, Chayama Kazuaki, Tanaka Saiyu, Fujimoto Kazuma, Anzai Keizo, Saibara Toshiji, Sata Michio, Itoh Yoshito, Nakajima Atsushi, Okanoue Takeshi,
Publication date 2014/08
Summary AIM:To investigate a simple noninvasive scoring system for predicting liver cirrhosis in nonalcoholic fatty liver disease (NAFLD) patients.METHODS:A total of 1048 patients with liver-biopsy-confirmed NAFLD were enrolled from nine hepatology centers in Japan (stage 0, 216; stage 1, 334; stage 2, 270; stage 3, 190; stage 4, 38). The weight and height of the patients were measured using a calibrated scale after requesting the patients to remove their shoes and any heavy clothing. Venous blood samples were obtained in the morning after the patients had fasted overnight for 12 h. Laboratory evaluation was performed in all patients. Statistical analysis was conducted using SPSS version 12.0. Continuous variables were expressed as mean ± SD.RESULTS:The optimal cutoff value of platelet count, serum albumin, and aminotransferase/alanine aminotransferase ratio (AAR) was set at < 15.3 10(4)/μL, < 4.0 g/dL, and > 0.9, respectively, by the receiver operating characteristic curve. These three variables were combined in an unweighted sum (platelet count = 1 point, serum albumin = 1 point, AAR = 1 point) to form an easily calculated composite score for predicting cirrhosis in NAFLD patients, called the PLALA (platelet, albumin, AAR) score. The diagnosis of PLALA ≥ 2 had sufficient accuracy for detecting liver cirrhosis in NAFLD patients.CONCLUSION:The PLALA score may be an ideal scoring system for detecting cirrhosis in NAFLD patients with sufficient accuracy and simplicity to be considered for clinical use.
DOI 10.3748/wjg.v20.i29.10108
PMID 25110437