ONO Masafumi
   Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine
   Position  
Article types Original article
Language English
Peer review Peer reviewed
Title Complications of radiofrequency ablation for hepatocellular carcinoma in a multicenter study: An analysis of 16 346 treated nodules in 13 283 patients.
Journal Formal name：Hepatology research : the official journal of the Japan Society of Hepatology
Abbreviation：Hepatol Res
ISSN code：1872034X/13866346
Domestic / ForeginDomestic
Volume, Issue, Page 42(11),pp.1058-64
Author and coauthor Koda Masahiko, Murawaki Yoshikazu, Hirooka Yasuaki, Kitamoto Mikiya, Ono Masafumi, Sakaeda Hiroshi, Joko Kouji, Sato Shuichi, Tamaki Katsuyoshi, Yamasaki Takahiro, Shibata Hiroshi, Shimoe Toshinari, Matsuda Tadakazu, Toshikuni Nobuyuki, Fujioka Shin-Ichi, Ohmoto Kenji, Nakamura Shinichiro, Kariyama Kazuya, Aikata Hiroshi, Kobayashi Yoshiyuki, Tsutsui Akemi
Publication date 2012/11
Summary AIM:  We surveyed multiple centers to identify types and frequency of complications and mortality rate associated with radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC).METHODS:  We distributed a questionnaire developed by members of the Chugoku-Shikoku Society for the Local Ablation Therapy of Hepatocellular Carcinoma to 20 centers and analyzed types and frequency of complications and mortality rate.RESULTS:  In total, 16 346 nodules were treated in 13 283 patients between January 1999 and November 2010. Five patients (0.038%) died: two from intraperitoneal hemorrhage, and one each from hemothorax, severe acute pancreatitis and perforation of the colon. In 16 346 treated nodules, 579 complications (3.54%) were observed, including 78 hemorrhages (0.477%), 276 hepatic injuries (1.69%), 113 extrahepatic organ injuries (0.691%) and 27 tumor progressions (0.17%). The centers that treated a large number of nodules and performed RFA modifications, such as use of artificial ascites, artificial pleural effusion and bile duct cooling, had low complication rates.CONCLUSION:  This study confirmed that RFA is a low-risk treatment for HCC and that sufficient experience and technical skill can reduce complications.
DOI 10.1111/j.1872-034X.2012.01025.x
PMID 22583706