ONO Masafumi
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Complications of radiofrequency ablation for hepatocellular carcinoma in a multicenter study: An analysis of 16 346 treated nodules in 13 283 patients. |
Journal | Formal name:Hepatology research : the official journal of the Japan Society of Hepatology Abbreviation:Hepatol Res ISSN code:1872034X/13866346 |
Domestic / Foregin | Domestic |
Volume, Issue, Page | 42(11),pp.1058-64 |
Author and coauthor | Koda Masahiko, Murawaki Yoshikazu, Hirooka Yasuaki, Kitamoto Mikiya, Ono Masafumi, Sakaeda Hiroshi, Joko Kouji, Sato Shuichi, Tamaki Katsuyoshi, Yamasaki Takahiro, Shibata Hiroshi, Shimoe Toshinari, Matsuda Tadakazu, Toshikuni Nobuyuki, Fujioka Shin-Ichi, Ohmoto Kenji, Nakamura Shinichiro, Kariyama Kazuya, Aikata Hiroshi, Kobayashi Yoshiyuki, Tsutsui Akemi |
Publication date | 2012/11 |
Summary | AIM: We surveyed multiple centers to identify types and frequency of complications and mortality rate associated with radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC).METHODS: We distributed a questionnaire developed by members of the Chugoku-Shikoku Society for the Local Ablation Therapy of Hepatocellular Carcinoma to 20 centers and analyzed types and frequency of complications and mortality rate.RESULTS: In total, 16 346 nodules were treated in 13 283 patients between January 1999 and November 2010. Five patients (0.038%) died: two from intraperitoneal hemorrhage, and one each from hemothorax, severe acute pancreatitis and perforation of the colon. In 16 346 treated nodules, 579 complications (3.54%) were observed, including 78 hemorrhages (0.477%), 276 hepatic injuries (1.69%), 113 extrahepatic organ injuries (0.691%) and 27 tumor progressions (0.17%). The centers that treated a large number of nodules and performed RFA modifications, such as use of artificial ascites, artificial pleural effusion and bile duct cooling, had low complication rates.CONCLUSION: This study confirmed that RFA is a low-risk treatment for HCC and that sufficient experience and technical skill can reduce complications. |
DOI | 10.1111/j.1872-034X.2012.01025.x |
PMID | 22583706 |