ONO Masafumi
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | New scoring system combining the FIB-4 index and cytokeratin-18 fragments for predicting steatohepatitis and liver fibrosis in patients with nonalcoholic fatty liver disease. |
Journal | Formal name:Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Abbreviation:Biomarkers ISSN code:13665804/1354750X |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 23(4),pp.328-334 |
Author and coauthor | Tada Toshifumi, Kumada Takashi, Toyoda Hidenori, Saibara Toshiji, Ono Masafumi, Kage Masayoshi |
Publication date | 2018/05 |
Summary | PURPOSE:To establish a new scoring system as a noninvasive tool for predicting steatohepatitis and liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).METHODS:A total of 170 patients histologically diagnosed with nonalcoholic steatohepatitis (NASH) (n = 130) or nonalcoholic fatty liver (NAFL) (n = 40) were enrolled. We analyzed receiver operating characteristic (ROC) curves and performed multivariate analysis to predict steatohepatitis and liver fibrosis.RESULTS:Multivariate analysis showed that cytokeratin-18 fragment (CK18-F) levels (≥278 U/L) (odds ratio [OR], 4.46; 95% confidence interval [CI], 1.42-14.00; p = 0.010) and the FIB-4 index (≥1.46) (OR, 4.54; 95% CI, 1.93-29.50; p = 0.004) were independently associated with prediction of NASH. We then established a new scoring system (named the FIC-22 score) for predicting NASH using CK18-F levels and FIB-4 index. The areas under the ROC curve (AUROCs) of the FIC-22 score and NAFIC score were 0.82 (95% CI, 0.75-0.89) and 0.71 (95% CI, 0.62-0.78) (p = 0.044). Additionally, the AUROC of the FIC-22 score for predicting the presence of fibrosis (F ≥ 1) was 0.78 (95% CI, 0.70-0.85).CONCLUSIONS:In patients with NAFLD, the FIC-22 score had high predictive accuracy not only for steatohepatitis but also for the presence of liver fibrosis. |
DOI | 10.1080/1354750X.2018.1425915 |
PMID | 29308929 |