佐藤 加代子
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position |
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Article types | Original article |
Language | English |
Peer review | Non peer reviewed |
Title | Functional profile of activated dendritic cells in unstable atherosclerotic plaque. |
Journal | Formal name:Basic research in cardiology Abbreviation:Basic Res Cardiol ISSN code:03008428 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 102(2),pp.123-32 |
Author and coauthor | Erbel Christian†, Sato Kayoko, Meyer Frederic B, Kopecky Stephen L, Frye Robert L, Goronzy Jörg J, Weyand Cornelia M |
Publication date | 2007/03 |
Summary | Activated and fully mature DC are represented in the inflammatory infiltrate characteristic for unstable carotid and coronary atheroma. Such DC produce chemokines, and thus can regulate the cell traffic into the lesion. Through the expression of the costimulatory ligand CD86, plaque-residing DC can augment T-cell stimulation and provide optimal stimulation conditions for T lymphocytes, resembling the microenvironment in organized lymphoid tissues. |
DOI | 10.1007/s00395-006-0636-x |
PMID | 17136419 |