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NIINAMI Hiroshi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
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| Article types | Review article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Effect of Diabetes Mellitus on Outcomes in Patients With Left Ventricular Assist Device - Analysis of Data From a Japanese National Database. |
| Journal | Formal name：Circulation journal : official journal of the Japanese Circulation Society Abbreviation：Circ J ISSN code：13474820/13469843 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 86(12),pp.1950-1958 |
| Author and coauthor | Yoshioka Daisuke†, Toda Koichi, Ono Minoru, Fukushima Norihide, Shiose Akira, Saiki Yoshikatsu, Usui Akihiko, Wakasa Satoru, Niinami Hiroshi, Matsumiya Goro, Arai Hirokuni, Sawa Yoshiki, Miyagawa Shigeru, |
| Publication date | 2022/11/25 |
| Summary | BACKGROUND:The objective of this study is to investigate the effect of preoperative diabetes on all-cause mortality and major postoperative complications among patients with continuous-flow left ventricular assist device (LVAD) by using data from a national database.Methods and Results: The 545 study patients who underwent primary HeartMateII implantation between 2013 and 2019 were divided into 2 groups according to their diabetes mellitus (DM) status; patients with DM (n=116) and patients without DM (n=429). First, the on-device survival and incidence of adverse events were evaluated. Second, after adjusting for patients' backgrounds, the change of laboratory data in the 2 groups were compared. Overall, on-device survival at 1, 2, and 3 years was almost equivalent between the 2 groups; it was 95%, 94%, and 91% in patients without DM, and 93%, 91%m and 91% in patients with DM (P=0.468) The incidence of adverse events was similar between 2 groups of patients, except for driveline exit site infection in the adjusted cohort. Cox proportional hazards regression analysis revealed younger age (HR: 0.98 (95% confidence interval (CI): 0.97-0.99, P=0.001) and presence of DM (HR: 1.83 (95% CI: 1.14-2.88), P=0.016) as significant predictors of driveline infection. Laboratory findings revealed no differences between groups throughout the periods.CONCLUSIONS:The clinical results after LVAD implantation in DM patients were comparable with those in non-DM patients, except for the driveline exit site infection. |
| DOI | 10.1253/circj.CJ-21-1056 |
| PMID | 35786688 |